Health-related quality of life in early Parkinson's disease: the impact of nonmotor symptoms.
Identifieur interne : 000562 ( Main/Exploration ); précédent : 000561; suivant : 000563Health-related quality of life in early Parkinson's disease: the impact of nonmotor symptoms.
Auteurs : Gordon W. Duncan [Royaume-Uni] ; Tien K. Khoo ; Alison J. Yarnall ; John T. O'Brien ; Shirley Y. Coleman ; David J. Brooks ; Roger A. Barker ; David J. BurnSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (therapeutic use), Cognition Disorders (etiology), Depression (etiology), Female, Health Status, Humans, Longitudinal Studies, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (psychology), Quality of Life (psychology), Retrospective Studies, Sleep Disorders (etiology), Statistics as Topic.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- complications : Parkinson Disease.
- drug therapy : Parkinson Disease.
- etiology : Cognition Disorders, Depression, Sleep Disorders.
- psychology : Parkinson Disease, Quality of Life.
- Aged, Female, Health Status, Humans, Longitudinal Studies, Male, Middle Aged, Retrospective Studies, Statistics as Topic.
Abstract
Nonmotor symptoms (NMS) are common in patients with established Parkinson's disease (PD) and have a major impact upon quality of life. We investigated the significance of NMS in relation to health-related quality of life (HRQoL) in patients with newly diagnosed PD. Patients and healthy controls were recruited as part of the Incidence of Cognitive Impairment in Cohorts with Longitudinal Evaluation in Parkinson's Disease Study. Prevalence of NMS was determined with the Non-Motor Symptom Questionnaire. HRQoL was recorded with the 39-item Parkinson's Disease Quality of Life Questionnaire (PDQ-39). Further assessments included measures of motor disability, depression, sleep, and cognition. One hundred and fifty-eight patients with newly diagnosed PD and 99 controls participated in this cross-sectional study. Patients reported greater numbers of NMS than controls (mean 8.3 ± 4.3 versus 2.8 ± 2.5 symptoms; P < 0.001). Patients reported lowest HRQoL in the domains assessing bodily discomfort, mobility, and activities of daily living. Motor and nonmotor symptoms impacted negatively upon HRQoL scores. Patients with the postural instability and gait difficulty motor subtype reported worse HRQoL, compared with those with tremor-dominant disease. Depression (P < 0.001), incomplete bowel emptying (P < 0.001), anxiety (P < 0.001), impaired concentration (P < 0.001), memory complaints (P < 0.001), and insomnia (P = 0.001) had the greatest negative impact upon HRQoL. NMS are common in patients with early PD and represent a significant cause of poorer health-related quality of life. Cognitive, neuropsychiatric, and sleep disturbances are particularly associated with reduced well-being. Screening and management of these symptoms should be prioritized at the time of diagnosis.
DOI: 10.1002/mds.25664
PubMed: 24123307
Affiliations:
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Yarnall</name></author><author><name sortKey="O Brien, John T" sort="O Brien, John T" uniqKey="O Brien J" first="John T" last="O'Brien">John T. O'Brien</name></author><author><name sortKey="Coleman, Shirley Y" sort="Coleman, Shirley Y" uniqKey="Coleman S" first="Shirley Y" last="Coleman">Shirley Y. Coleman</name></author><author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J" last="Brooks">David J. Brooks</name></author><author><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger A" last="Barker">Roger A. Barker</name></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24123307</idno><idno type="pmid">24123307</idno><idno type="doi">10.1002/mds.25664</idno><idno type="wicri:Area/PubMed/Corpus">000738</idno><idno type="wicri:Area/PubMed/Curation">000738</idno><idno type="wicri:Area/PubMed/Checkpoint">000572</idno><idno type="wicri:Area/Ncbi/Merge">003D59</idno><idno type="wicri:Area/Ncbi/Curation">003D59</idno><idno type="wicri:Area/Ncbi/Checkpoint">003D59</idno><idno type="wicri:Area/Main/Merge">000562</idno><idno type="wicri:Area/Main/Curation">000562</idno><idno type="wicri:Area/Main/Exploration">000562</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Health-related quality of life in early Parkinson's disease: the impact of nonmotor symptoms.</title><author><name sortKey="Duncan, Gordon W" sort="Duncan, Gordon W" uniqKey="Duncan G" first="Gordon W" last="Duncan">Gordon W. Duncan</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Ageing and Health, Newcastle University, Newcastle, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute for Ageing and Health, Newcastle University, Newcastle</wicri:regionArea><wicri:noRegion>Newcastle</wicri:noRegion></affiliation></author><author><name sortKey="Khoo, Tien K" sort="Khoo, Tien K" uniqKey="Khoo T" first="Tien K" last="Khoo">Tien K. Khoo</name></author><author><name sortKey="Yarnall, Alison J" sort="Yarnall, Alison J" uniqKey="Yarnall A" first="Alison J" last="Yarnall">Alison J. Yarnall</name></author><author><name sortKey="O Brien, John T" sort="O Brien, John T" uniqKey="O Brien J" first="John T" last="O'Brien">John T. O'Brien</name></author><author><name sortKey="Coleman, Shirley Y" sort="Coleman, Shirley Y" uniqKey="Coleman S" first="Shirley Y" last="Coleman">Shirley Y. Coleman</name></author><author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J" last="Brooks">David J. Brooks</name></author><author><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger A" last="Barker">Roger A. Barker</name></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiparkinson Agents (therapeutic use)</term><term>Cognition Disorders (etiology)</term><term>Depression (etiology)</term><term>Female</term><term>Health Status</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (psychology)</term><term>Quality of Life (psychology)</term><term>Retrospective Studies</term><term>Sleep Disorders (etiology)</term><term>Statistics as Topic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Depression</term><term>Sleep Disorders</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term><term>Quality of Life</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Health Status</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term><term>Statistics as Topic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nonmotor symptoms (NMS) are common in patients with established Parkinson's disease (PD) and have a major impact upon quality of life. We investigated the significance of NMS in relation to health-related quality of life (HRQoL) in patients with newly diagnosed PD. Patients and healthy controls were recruited as part of the Incidence of Cognitive Impairment in Cohorts with Longitudinal Evaluation in Parkinson's Disease Study. Prevalence of NMS was determined with the Non-Motor Symptom Questionnaire. HRQoL was recorded with the 39-item Parkinson's Disease Quality of Life Questionnaire (PDQ-39). Further assessments included measures of motor disability, depression, sleep, and cognition. One hundred and fifty-eight patients with newly diagnosed PD and 99 controls participated in this cross-sectional study. Patients reported greater numbers of NMS than controls (mean 8.3 ± 4.3 versus 2.8 ± 2.5 symptoms; P < 0.001). Patients reported lowest HRQoL in the domains assessing bodily discomfort, mobility, and activities of daily living. Motor and nonmotor symptoms impacted negatively upon HRQoL scores. Patients with the postural instability and gait difficulty motor subtype reported worse HRQoL, compared with those with tremor-dominant disease. Depression (P < 0.001), incomplete bowel emptying (P < 0.001), anxiety (P < 0.001), impaired concentration (P < 0.001), memory complaints (P < 0.001), and insomnia (P = 0.001) had the greatest negative impact upon HRQoL. NMS are common in patients with early PD and represent a significant cause of poorer health-related quality of life. Cognitive, neuropsychiatric, and sleep disturbances are particularly associated with reduced well-being. Screening and management of these symptoms should be prioritized at the time of diagnosis.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><noCountry><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger A" last="Barker">Roger A. Barker</name><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J" last="Brooks">David J. Brooks</name><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name><name sortKey="Coleman, Shirley Y" sort="Coleman, Shirley Y" uniqKey="Coleman S" first="Shirley Y" last="Coleman">Shirley Y. Coleman</name><name sortKey="Khoo, Tien K" sort="Khoo, Tien K" uniqKey="Khoo T" first="Tien K" last="Khoo">Tien K. Khoo</name><name sortKey="O Brien, John T" sort="O Brien, John T" uniqKey="O Brien J" first="John T" last="O'Brien">John T. O'Brien</name><name sortKey="Yarnall, Alison J" sort="Yarnall, Alison J" uniqKey="Yarnall A" first="Alison J" last="Yarnall">Alison J. Yarnall</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Duncan, Gordon W" sort="Duncan, Gordon W" uniqKey="Duncan G" first="Gordon W" last="Duncan">Gordon W. 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